Mike
VNU High School for the Gifted
Our students
Recep
London School of Economics (LSE)
Abdul
Eton College
Rena
University of Leiden
Tracy
Colby College, Princeton University, Harvard Medical School
Clara
Fulbright University
Bao
Berlin University of Technology
Natalia
Leweston School, University of Cambridge, WHO
Royal
University of North Carolina at Chapel Hill
Catherine
Nanyang Junior College
Hazel
Stanford University
Cindy
VinSchool Hanoi
Mai
The Hotchkiss School
Dan
University of Queensland
Kevin
Farragut Academy
Ly
Lake Forest Academy
/ Research and AI engineering fellowships for students aged 14 and above /
Work at the frontier of knowledge while you are still at school.
Because of AI, what humanity knows is moving faster than any curriculum can follow. Two Sigma Lab closes that gap by pairing exceptional students with professor-level faculty and professional mentors to solve unresolved problems in science, technology and engineering, and to build the papers, tools and ventures that show the world what they can do.
/ our fellows /
Work that admissions officers and employers can verify
Two Sigma Lab fellows finish with artefacts that stand on their own: papers on public preprint servers and, where the work earns it, in international journals, and working AI tools. Students mentored by our founder and faculty have won places at universities including Cambridge, Harvard, Oxford, Stanford and MIT.
- of students mentored by our founder and faculty were admitted to their dream college
- 92%
MikeVNU High School for the Gifted • Ho Chi Minh City, VietnamPublished in EngRxiv (opens in a new tab) Joining Two Sigma Lab is a big step for me. I like many different subjects, and this program lets me bring them together in one research project. I’m looking forward to meeting my mentor every week and learning how to do research the right way. I want to keep studying after high school, and I think this will help me get there.
RecepLondon School of Economics (LSE) • London, UK Titus was instrumental in helping me do research that got me into Oxford, LSE and several other prestigious programs and universities. He is an amazing scientist and communicator and understands exactly what universities are looking for in a candidate.
AbdulEton College • UKOrwell Scholar, Two Sigma Scholar Two Sigma Lab provides an outstanding opportunity to conduct real research with world-class faculty. As a scholarship student, I’ve seen firsthand the commitment that Titus and the team have to supporting students like myself with potential and intellectual curiosity.
RenaUniversity of Leiden • Netherlands I worked with Titus and Two Sigma Lab for six months, and his mentorship reshaped the way I approached research and applications. It strengthened my applications and got me into my dream master’s program.
TracyColby College, Princeton University, Harvard Medical School • USA Titus has been an exceptional mentor who pushed me to aim higher and taught me how to communicate ideas with clarity and impact. These skills were crucial in securing research opportunities at Princeton and Harvard.
ClaraFulbright University • Vietnam Working with Titus and Two Sigma Lab was a practical and valuable experience that strengthened my scholarship applications and academic prospects. Under their guidance, I developed work that was strong enough to move toward publication.
BaoBerlin University of Technology • Germany The research experience with Two Sigma Lab really opened my eyes to how different fields intertwine, and how I can create innovation by identifying these intersections. Finally, I achieved my dream internship and career through the referral given by my mentor. It was life-changing for me.
NataliaLeweston School, University of Cambridge, WHO • UK I am grateful for all the support from Two Sigma Lab’s founder, Titus, for my research project and scientific career. The work with him has deepened my understanding of neuroscience, and how it intersects with other fields. These insights have led me to a fulfilling career in public health after my graduation.
RoyalUniversity of North Carolina at Chapel Hill • USA Working with Two Sigma Lab has been incredibly valuable throughout my undergraduate research journey, especially in preparing research proposals and manuscripts for scientific publication. Thanks to my mentor, I’ve grown academically, professionally, and personally.
CatherineNanyang Junior College • Singapore Having had little to no experience in coding and computational biology, I felt like a fish out of water when I first started on this project with Two Sigma Lab. But with step-by-step guidance from my supervisor and instant feedback from the Two Sigma AI tools, I was able to tackle the project.
HazelStanford University • USA At Two Sigma Lab, I was introduced to AI-driven tools that provided clear guidance in tackling coding challenges and creating effective data visualizations. It has been challenging yet rewarding, and equipped me with a versatile skill set.
CindyVinSchool Hanoi I’m thrilled to join the Two Sigma Lab Fellowship for the opportunity to turn my interest in neuroscience into meaningful, structured research while receiving close mentorship from faculty. Most importantly, I’m drawn to an environment that will challenge me and encourage me to aim higher.
MaiThe Hotchkiss School • Connecticut, USA I’m really excited to join the Two Sigma Lab Fellowship. I have always asked a lot of questions, and now I get to turn one of them into a real research project. Working one-on-one with an expert mentor will help me learn how real scientists think. I hope this experience will prepare me for college and beyond.
DanUniversity of Queensland • Australia I’m excited to join the Two Sigma Lab Fellowship because of the opportunity this program would bring me to transform interdisciplinary curiosity into rigorous, impactful research, along with the chance to work one-on-one with the faculty who can guide me in pursuing higher studies.
KevinFarragut Academy • USA I am truly excited to join the Two Sigma Lab Fellowship. I firmly believe that the support from Two Sigma Lab will give me wings to soar closer to my dream of becoming a doctor. To me, this opportunity is more than a fellowship; it is a stepping stone towards the future I aspire to build.
LyLake Forest Academy • USA I’m excited to be able to use the guidance of knowledgeable experts to create and hopefully publish a paper.
Students mentored by our founder and faculty have been admitted to
/ our mission /
The frontier of knowledge is moving faster than any school can teach.
With AI, the pace of discovery in science, technology and engineering has broken away from the pace of education, and the gap keeps widening.
Two Sigma Lab closes that gap for students who are ready for it. We pair each student with professor-level faculty and professional mentors to work on unresolved problems and build something real: a research paper, a working piece of technology or the beginnings of a company. That work carries weight where it matters, in internship, job and university applications decided by people trained to recognise outlier talent.
Every admissions officer can recognise an outlier talent. It takes outlier talents to shape them.
/ your fellowship /
From an open problem to an artefact the world can see
STEP 1
Map
Our Scientific Atlas charts unresolved problems across thousands of fields in science, technology and engineering. You find the ones where your talent can make a difference now.
STEP 2
Match
You are paired with a professor-level faculty member or a professional mentor who works on that problem for a living. Every mentor is a working professional. None is a student.
STEP 3
Build
You generate data, write code, test ideas and defend your reasoning the way practising scientists and engineers do, with weekly sessions and AI tools that take the busywork so you can focus on the thinking.
STEP 4
Publish
You finish with an artefact: a manuscript on a preprint server and, where the work earns it, in an international peer-reviewed journal; a working tool or product; or a venture with its first users.
STEP 5
Be vouched for
Your faculty put their name to your work as co-authors and supervisors. You join a network of alumni, faculty and partners that grows every year and can speak for what you have done.
Open problems. Professional mentors. Artefacts the world can see. //
/ our faculty /
Your mentors work at the frontier of science and technology.
Two Sigma Lab faculty are professor-level researchers and senior practitioners, trained at Harvard, Cambridge, Oxford, MIT, Yale and their peers, who publish in leading journals, build technology used by millions and win international awards. They mentor because they want the next generation to start earlier than they did. Every mentor is a working professional, and we have never placed a student in a mentoring role.
- citations
- 19,000+
- peer-reviewed papers
- 260+
- in top-quartile (Q1) journals
- 80%
Sources: Google Scholar, SCImago Journal Rank and LinkedIn, November 2026
MD, PhD in Neuroscience & Biotechnology, University of Cambridge, Harvard University, MIT & Yale
(opens in a new tab)
Honorary Professor at the University of Auckland, NZ, PhD in Biochemistry, DSc in Computational Biology
(opens in a new tab)
PhD in Sociocultural Anthropology, Yale University, USA
(opens in a new tab)
PhD in Biomedical Sciences, Johns Hopkins University, USA
(opens in a new tab)
PhD in Human Behavior & Sociology, University of Cambridge, UK
(opens in a new tab)
PhD in Biomedical Sciences, Harvard University, USA
(opens in a new tab)
PhD in Music History & Literature, Yale University, USA
(opens in a new tab)
PhD in Health Sciences, University of Copenhagen, DK
(opens in a new tab)
PhD in Chemistry, University of Cambridge & Stanford University, UK, USA
(opens in a new tab)
PhD in Genomics & Anthropology, Princeton University, USA
Senior Product Designer at JPMorgan Chase, MS in User Experience and Interaction Design, Thomas Jefferson University
Amnesty Media Award Winning Journalist & Filmmaker
Director of Product Strategy, Modus Create, and LinkedIn Learning instructor
Product Designer in AI-powered Learning, Wellness, and Inclusion and MA in EMDD, Ball State University
UX practitioner with 13 years of experience, MS in Human Computer Interaction, University of Maryland Baltimore County
Researcher at Meta, PhD in Artificial Intelligence & Computer Science at Imperial College London, UK
PhD in Psychology, University of Cambridge, UK
Global Leader in Strategic AI, MEng in Computer Science and Electrical Engineering
Food scientist with expertise in biotechnology, nutrition, and sustainable food innovation
Former Creator Growth UX Lead at Google, now at Ebury, with 15+ years building digital products
/ our promise /
We put our name to your work.
When a Two Sigma Lab fellow publishes a paper, a faculty member stands beside them as co-author. When a fellow ships a tool or founds a venture, a mentor who built such things for a living has supervised every step. Our faculty sign their names to what our students make, and they answer for it to journal editors, admissions committees and employers.
That is why every fellow is chosen by interview before any work begins, and why we take on only the students our faculty are willing to vouch for. A paper with a professor’s name on it, a product with a senior engineer behind it and a reference from someone who has watched you work are things no template can produce.
Co-authored, never ghost-written.
Students are first authors. Faculty are co-authors who vouch for the rigour.
Published where it is checked.
Every completed project goes on a public preprint server, and the strongest go on to international peer review.
References from people who were there.
Faculty who supervised the work can be asked to speak for it, for university, scholarship and career applications.
/ our fellowships /
Every problem is real. Every project is yours.
Each fellow works on an unresolved problem chosen from the Atlas and shaped with their faculty, so no two projects are alike and none is a template. You choose the depth: a three-month research cohort or capstone, a six-month fellowship aimed at international publication or a working AI product, or a ten-month fellowship that becomes the centrepiece of your university applications.
Fellowship Pathways
Research Cohort
- Description:
- Small-group research on an open problem, designed and mentored by faculty.
- Duration:
- 3 months
Capstone Fellowship
- Description:
- One idea, one mentor, one finished manuscript or portfolio.
- Duration:
- 3 months
Advanced Fellowship
- Description:
- Deep faculty engagement towards an international publication or a fully developed innovation project.
- Duration:
- 6 months
AI Impact Fellowship
- Description:
- Build an AI tool that addresses a real problem at scale, supervised by senior engineers.
- Duration:
- 6 months
Two Sigma Fellowship
- Description:
- The full arc from open problem to professional-grade artefact, built to anchor your university applications.
- Duration:
- 10 months
Research that tells your application's story
We work closely with college counsellors, and many of our fellows come to us through them. Where a student has an application persona in mind, we make sure the problem they choose, the artefact they build and the people who vouch for them all point in the same direction. For families who want it, Two Sigma Lab offers an invitation-only admissions track in which the fellowship sits inside end-to-end counselling for the UK and the US. Ask about it when you apply.
/ selection /
We work with the world’s top 10% of students.
Two Sigma Lab accepts high school students aged 14 and above and undergraduates from anywhere in the world. Our fellows come from schools in the UK, the US and Vietnam, and admission runs the same way for every one of them: an application, a committee review and an interview with a core faculty member. We fund 5 scholarship places a year for students whose talent outruns their circumstances.
We look for students who:
- Ask big questions and want to work on problems nobody has solved
- Show early ability in research, engineering or building things
- Take to new technology and unconventional ways of thinking
- Want their work to matter beyond the classroom
STEP 1
Application
STEP 2
Committee review
STEP 3
Interview
STEP 4
Decision
/ founder /
It takes outlier talents to shape the next generation of them.
Titus Hoang, MD, PhD
Founder & CEO
Titus Hoang, MD, PhD, is a physician-scientist, educator and entrepreneur. He trained at the Free University of Berlin, Cambridge, Harvard, MIT and Yale, published in Science, PNAS, eLife and The EMBO Journal, interviewed for Cambridge admissions, and spent fifteen years mentoring students and professionals worldwide. He founded Two Sigma Lab, Inc. so that leading researchers and practitioners would take on the students who will one day replace them.
Start at the frontier.
Applications are accepted on a rolling basis. Places are limited to the students our faculty are willing to vouch for.
(opens in a new tab)Make your work impossible to ignore / >
Frequently Asked Questions
Questions we think you might like answers to
What is Two Sigma Lab?
Two Sigma Lab is a research and AI engineering institute for high school students aged 14 and above and for undergraduates. Because of AI, knowledge now moves faster than any curriculum can follow. We close that gap by pairing exceptional students with professor-level faculty and professional mentors to work on unresolved problems in science, technology and engineering, and to finish with a paper, a working technology or a venture that the world can see.
How is Two Sigma Lab different from other online research programs?
Three ways. We start from the world’s open problems, mapped in our Scientific Atlas, rather than from a menu of topics. Every mentor is a working professional: a professor-level researcher or a senior engineer, designer or founder, and none is a student. And we put our name to your work: faculty co-author and supervise it, publish it where it can be checked, and can speak for it afterwards.
Who are the faculty, and what are their qualifications?
Our faculty are professor-level researchers and senior practitioners trained at Harvard, Cambridge, Oxford, MIT, Yale and their peers. They publish in leading journals, build technology used at scale and win international awards. Every one of them is active in their field today.
How selective are admissions?
Admission is highly selective. We only work with the top 10% of students worldwide, and we select on what you can do, not on grades alone. As a benchmark, our typical students have GPAs above 3.5 and SAT scores above 1500.
Do I need prior experience in AI or research to join?
You need curiosity, persistence and the readiness to work on a problem nobody has solved. We teach the rest.
What is the time commitment required for the programs?
Time commitment varies by fellowship pathway. Students typically spend 10 hours of research time weekly. Students meet weekly with faculty over a period of three to ten months, with additional independent research required between sessions.
What are the costs associated with participating in a research program?
Tuition ranges from $4,000 to $10,000, depending on the fellowship pathway. For details on fees and payment options, please contact us at info@twosigmalab.com. We also award merit-based scholarships on a case-by-case basis, with 5 funded places a year for students whose talent outruns their circumstances.
Who owns the research or intellectual property created?
Students are always credited as primary authors on publications and retain ownership of their intellectual property. Faculty may serve as co-authors to validate rigor and standards, but all work is transparently attributed to the student.
How is mentorship delivered?
Mentorship is delivered online through structured sessions with faculty, supported by asynchronous feedback and AI copilots for routine tasks. This model ensures students receive sustained, personalized guidance while developing independent research skills.
What types of research or innovation projects can I undertake?
Fellows pursue projects that reflect their passions and goals, from original scientific research to the design of AI tools with measurable community impact. All projects are held to rigorous academic and professional standards.
Where will my work be published?
All completed projects are published on scientific preprint servers such as arXiv or bioRxiv, ensuring your work is transparent, verifiable, and publicly accessible. Beyond this, our faculty work with motivated students to pursue publication in peer-reviewed international journals. However, final acceptance depends on the quality of the work, the student’s effort, and the standards of each journal. We cannot ethically guarantee journal publication, but we do guarantee that your project will meet professional standards and be accessible to the public.
What universities have students been admitted to?
Our students have secured admission to leading global universities, including Ivy League and Oxbridge institutions. Each project is designed to provide distinction in admissions, complementing strong academic records and test scores.
What support is available if I feel stuck or overwhelmed?
Every student is matched with a dedicated faculty mentor who provides both academic and personal guidance. In addition, our structured curriculum and AI copilots reduce busywork, allowing students to focus on their core ideas.
Can I collaborate with other students?
Yes. While the core of our program is one-on-one mentorship, students are invited to join our broader network of fellows and alumni for discussions, workshops, and collaborations.
Do I receive a credential or certificate upon completion?
Yes. In addition to publications or innovation portfolios, all students who successfully complete a fellowship receive a certificate from Two Sigma Lab, verifying their participation and the rigor of their work.
How do I apply to join Two Sigma Lab?
Applications are reviewed on a rolling basis. Prospective fellows may apply through our application page, where they outline their interests and goals. Selected applicants are invited to an interview before final admission decisions are made.
